Portfolio • 4 flagship programs open for evaluation
Discovery portfolio
Search and filter our 35 active discovery targets across five industrial domains and six structural archetypes: 16.6+ million distinct candidates indexed, nearly 1 million folded 3D models, and sub-angstrom catalytic caliper validation.
35
Live discovery targets
Active biophysics & biocatalysis funnels
16.6M+
Candidate records in registry
Unified candidate registry
Nearly 1M
Folded 3D protein models
Distinct sequences with predicted structure
>25,000/s
Edge neural sieve throughput
Apple Neural Engine triage at <10W
Showing all programs
Source: Unified candidate registry and verified structure repository, measured September 2026
| Domain | Campaign | Mined candidates | Folded 3D models | Stage gate | Target / mechanism | Lead candidate ID | Expression host | Diligence |
|---|---|---|---|---|---|---|---|---|
| Remediation | PFAS Defluorinasespfas |
1,268,257 | 865 | In Silico Validated | Targeted electrostatic clamp & active-site geometry for ambient C–F cleavage | DBM-PFAS |
E. coli BL21(DE3) | Option → |
| Remediation | Xenobiotic hydro-dehalogenasesxenobio_hydro_dehal |
8,088 | 2,263 | In Silico Validated | Asp-His-Acid catalytic triad for hydrolytic & reductive dehalogenation | DBM-XDH |
Mortierella / E. coli | Option → |
| Remediation | Metal detoxification & redoxmetal_detox_redox |
2,729,369 | 75 | In Silico Validated | Cys-thiolate redox pair for heavy-metal redox (As, Cr, Pb, Hg) | DBM-MDR |
Pichia pastoris [pPICZα A] | Option → |
| Remediation | LPS endotoxin sensorslps_endotoxin_sensor |
696,894 | 25 | In Silico Validated | Bipartite Lipid A diphosphate ring sensor with basic motif for rapid pyrogen detection | DBM-LES |
Komagataella phaffii | Option → |
| Remediation | Self-healing concrete ureasesself_healing_ureases |
153,188 | 0 (Panel) | In Silico Validated | Binuclear Ni2+ amidohydrolase for accelerated CaCO3 crack bio-calcification | DBM-SHU |
Sporosarcina pasteurii | Option → |
| Climate | Ice-nucleating proteinsinp |
724,246 | 627,000+ | CRO Synthesis Queued | Class A ice nucleation at -1.7°C; C3 trimer & nanoconfined ice press | DBM-INP | A. niger / P. pastoris | Dossier → |
| Climate | Alkaline DAC Carbonic Anhydrasedac_carbonic_anhydrase |
167,917 | 9,277 | In Silico Validated | Accelerated CO2 hydration at alkaline pH in direct-air capture scrubbers | DBM-DAC |
P. pastoris / E. coli | Option → |
| Climate | pMMO / MMO Methanotrophspmmo_methanotroph |
41,198 | 4,774 | In Silico Validated | Ambient methane-to-methanol oxidation via copper histidine brace & diiron core | DBM-PMMO |
Methylococcus capsulatus | Option → |
| Climate | Carboxysome shell proteinscarboxysome |
8,318 | 2,831 | In Silico Validated | Self-assembling hexameric BMC shell with pores selective for HCO3- | DBM-BMC |
Synechococcus / E. coli | Option → |
| Polymers | Arctic Marine PETasepetase |
11,282,946 | 101,927 | In Silico Validated | PET depolymerization at 0°C–15°C; 134 salt bridges, 0 disulfides | DBM-PETase | Komagataella phaffii [pPIC9K] | Dossier → |
| Polymers | Plastizyme PA/PU proteasesplastizyme_pa_pu |
29,397 | 75 | In Silico Validated | Hydrolysis of synthetic polyamide (nylon) and polyurethane carbamate ester bonds | DBM-PLZ |
Pichia pastoris | Option → |
| Polymers | CAZy LPMO oxidasescazy_lpmo |
4,989 | 24 | In Silico Validated | Flat aromatic binding cleft with stacking subsites for oxidative polymer cleavage | DBM-LPMO |
Pichia pastoris [pPICZα A] | Option → |
| Polymers | Insect gut degradersinsect_gut_degrader |
5,368 | 131 | In Silico Validated | Polyolefin & lignin degradation candidates from insect gut metagenomes | DBM-IGD |
Bacillus / A. niger | Option → |
| Polymers | Rare-sugar isomerasesrare_sugar_isomerases |
3,620 | 1 | In Silico Validated | Octahedral metal TIM-barrel for C5/C6 sugar isomerization | DBM-RSI |
Bacillus subtilis / E. coli | Option → |
| Minerals | REE biomining & lanmodulinree_biomining |
225,012 | 517 | In Silico Validated | EF-hand carboxylate cage for selective picomolar Nd3+ and Dy3+ binding | DBM-REE |
P. pastoris [pPICZα A] | Option → |
| Minerals | Conductive bacterial pilinsconductive_pilins |
42,478 | 3 | In Silico Validated | Aromatic π-stacked pilin nanowires for bioelectronics | DBM-PIL |
Geobacter sulfurreducens | Option → |
| Minerals | Magnetosome scaffoldingmagnetosome |
177,325 | 220 | In Silico Validated | Single-domain magnetite (Fe3O4) biomineralization & lipid membrane templating | DBM-MAG |
Magnetospirillum gryphiswaldense | Option → |
| Minerals | Biomineralization & nacreinbiomineralization |
107,341 | 7,412 | In Silico Validated | Carboxylate facet registry templating aragonite / calcite nacre scaffolding | DBM-BIO |
Aspergillus / E. coli | Option → |
| Materials | Lichen PKS & extremophile IDPslichen_pks |
382,187 | 5,766 | In Silico Validated | Non-reducing PKS modular architecture for bioactive secondary metabolites | DBM-PKS |
Streptomyces / A. niger | Option → |
| Materials | Anhydrobiotic IDPsanhydrobiotic_idp |
3,076 | 61 | In Silico Validated | Vitrification & liquid-liquid phase separation for desiccation tolerance | DBM-IDP |
Pichia pastoris | Option → |
| Materials | Silk fibers & marine adhesivessilk_fiber |
237,982 | 663 | In Silico Validated | Poly-Ala/Gly-Gly-X nanocrystalline β-sheets for ultra-high tensile strength | DBM-SLK |
P. pastoris / T. reesei | Option → |
| Materials | Barnacle cement polymersmarine_adhesive |
932,875 | 4 | In Silico Validated | Cross-linking structural adhesives that cure underwater | DBM-BAR |
Pichia pastoris | Option → |
| Materials | Cuttlefish reflectinscuttlefish_reflectin |
2,941 | 20 | In Silico Validated | Bragg-reflector condensation for tunable refractive index & IR stealth | DBM-REF |
Escherichia coli | Option → |
| Materials | Bombardier beetle peroxidasebombardier_peroxidase |
2,176 | 225 | In Silico Validated | Proximal His-heme coordination for peroxide decomposition and oxidation | DBM-POD |
Pichia pastoris / E. coli | Option → |
| Materials | Mechanobiotic proteinsmechanobiotic |
4,150 | 36 | In Silico Validated | Mechanosensitive domain that unfolds under hydrodynamic shear | DBM-MEC |
Escherichia coli | Option → |
| Materials | Serum-free adhesion scaffoldsserum_free_adhesion_scaffold |
41,266 | 25 | In Silico Validated | Multivalent RGD integrin-binding matrix for animal-free culture media | DBM-SFA |
Pichia pastoris | Option → |
Mined and folded counts are file counts from the pipeline output tree, measured 29–30 September 2026. Scorer status says only that a campaign scorer has been run — it is not a count of candidates that pass. The scores held in the database are a cumulative historical record written by earlier versions of the scoring code: none of the counted rows were produced by the scorer in the tree today, and a live re-score of a stratified sample correlates with the stored values at Spearman 0.02. A full re-score has not been run, so we publish no current passing count.
What the stage gates mean
A development stage gate indicates experimental and computational milestones across our discovery campaigns.
- In Silico Validated
- Metagenomic candidate screened, full 3D structure predicted, and stability verified via explicit-solvent molecular dynamics.
- CRO Synthesis Queued
- Codon-optimized gene design completed and expression vector queued for heterologous synthesis with partner CROs.
- USPTO Patent Filed
- Priority patent application filed with the USPTO covering novel sequence compositions and functional uses.