Portfolio • 8 featured leads & 64 active targets

Discovery portfolio

Sixty-four enzyme, peptide, and protein programs drawn from 3.1 billion microbial sequences and 1.2 million 3D models. Click any staged row to inspect its specs.

A predicted four-chain protein assembly from this portfolio, with two palladium ions held between the chains by histidine side chains.

Live discovery targets

Active enzyme & biomaterial programs

3.1B+

Distinct sequences evaluated

Across global extremophile metagenomes

1.2M+

Full-length 3D models

Monomers & co-folded multimers

21,631/s

3D structural throughput

Measured on one 686k-structure geometry sweep, 16 workers

Showing all programs

Select any program row to view its technical dossier

Domain	Campaign	Mined candidates	Full-length 3D models	Development stage	Target / mechanism	Lead ID	Diligence
Remediation	PFAS Defluorinases `pfas`	1,268,257	27,934	Candidate	Targeted electrostatic clamp & active-site geometry for ambient C–F cleavage	`DB-PFAS1`
Remediation	Xenobiotic hydro-dehalogenases `xenobio_hydro_dehal`	8,088	10,990	Scored and simulated	Asp-His-Acid catalytic triad for hydrolytic & reductive dehalogenation	`DB-XDH`
Remediation	Metal detoxification & redox `metal_detox_redox`	2,729,369	34,291	Scored and simulated	Cys-thiolate redox pair for heavy-metal redox (As, Cr, Pb, Hg)	`DB-MDR`
Remediation	LPS endotoxin sensors `lps_endotoxin_sensor`	2,687,958	47,736	Scored and simulated	Bipartite Lipid A diphosphate ring sensor with basic motif for rapid pyrogen detection	`DB-LES`
Remediation	Self-healing concrete ureases `self_healing_ureases`	1,056,230	9,708	Candidate	Binuclear Ni2+ amidohydrolase for accelerated CaCO3 crack bio-calcification	`DB-MICP1`
Remediation	Biofilm EPS dispersins `biofilm_eps_dispersin`	53,648	11,606	Candidate	Glycoside hydrolase active cleft disrupting pathogen exopolysaccharide matrix	`DB-BED`
Remediation	High-temperature exothermic peroxidases `bombardier_peroxidase`	4,130,525	23,250	Scored and simulated	Heme-coordinated peroxidase core for high-temperature exothermic catalysis	`DB-BPO`
Climate	Ice-nucleating & cryopreservation proteins `inp`	—^‡	—^‡	CRO Synthesis Queued	Cell-free soluble ice nucleators and non-nucleating ice-recrystallization inhibitors for freeze-drying and cold storage	`DB-IRI1 / DB-INP1/2`
Climate	Direct air capture carbonic anhydrases `dac_carbonic_anhydrase`	19,207	29,039	Scored and simulated	Rigidified Zn-coordination shell with His proton shuttle for high-pH point-source CO2 capture	`DB-DCA`
Climate	Particulate methane monooxygenases `pmmo_methanotroph`	4,715	11,138	Scored and simulated	Histidine-brace copper active center for biological methane-to-methanol conversion	`DB-PMMO`
Climate	Soluble methane monooxygenases `mmo_methanotroph`	36,483	30,811	Scored and simulated	Carboxylate-bridged diiron hydroxylase core (MMOH/MmoX) for methane oxidation	`DB-SMMO`
Climate	Carboxysome shell scaffolds `carboxysome`	8,318	31,136	Candidate	Self-assembling hexameric microcompartment shell for ultra-high local CO2 enrichment	`DB-CBX`
Polymers	Processive PET depolymerases `petase`	11,282,946	19,084	Candidate	Four aligned Ser-His-Asp active sites along a 46 Å aromatic binding groove for aqueous polyester breakdown	`DB-PETase`
Polymers	Polyamide / polyurethane hydrolases `plastizyme_pa_pu`	29,397	10,987	Scored and simulated	Multi-triad surface depolymerases and amidases cleaving synthetic nylon and polyurethane bonds	`DB-PPU`
Polymers	Lytic polysaccharide monooxygenases `cazy_lpmo`	175,493	31,208	Scored and simulated	Mono-copper histidine-brace active site for oxidative cellulose & chitin cleavage	`DB-LPMO`
Polymers	Insect gut plastic hydrolases `insect_gut_degrader`	5,368	19,286	Scored and simulated	Adapted esterase/amidase catalytic clefts for refractory polyolefin degradation	`DB-IGD`
Minerals	Lanthanide-selective biomining `ree_biomining`	237,925	24,132	Scored and simulated	Rigid EF-hand coordination loops with pre-organized Asp/Glu carboxylate pockets designed for selective Nd/Dy/Tb recovery	`DB-REE1`
Minerals	High-affinity lanmodulins & metallocages `lanmodulin_reo`	2,584	21,662	Synthesized	36-AA lanthanide macrocycle (DB-LANM1) & 25-AA D2 binuclear Zn2+ metallocage (DB-ZNCAGE1)	`DB-LANM1 / DB-ZNCAGE1`
Minerals	Conductive protein nanowires `conductive_pilins`	17,705,186	81,618	Scored and simulated	Aromatic percolation lattice (Phe/Tyr) for long-range electron transport	`DB-CPN`
Minerals	Magnetite biomineralization scaffolds `magnetosome`	14,097,952	40,305	Scored and simulated	Ferrimagnetic iron oxide nucleating face for monodisperse magnetic nanoparticles	`DB-MAG`
Minerals	Tooth enamel & bone remineralization proteins `biomineralization`	59,543	67,751	Scored and simulated	Rigid 9.420 Å α-solenoid rods with calcium- and phosphate-binding ladders matching human tooth enamel	`DB-SOL1`
Minerals	Graphene nanomaterial assemblers `graphene_nanomaterial_assembler`	12,745	40,217	Candidate	Planar 2D aromatic array (Tyr/Phe/Trp) for epitaxial templating & exfoliation of carbon nanomaterials	`DB-GNA`
Biomaterials	Lichen polyketide synthases `lichen_pks`	294,397	7,218	Scored and simulated	Iterative Type I PKS multi-domain assembly for UV-protectant phenolic scaffolds	`DB-PKS`
Biomaterials	Lichen desiccation IDPs `lichen_idp`	2,295,715	31,122	Candidate	Intrinsically disordered LEA chaperone undergoing disorder-to-order glass protection	`DB-LIDP`
Biomaterials	Anhydrobiotic vitrification IDPs `anhydrobiotic_idp`	48,595	41,063	Scored and simulated	Heat-stable disordered biopolymer inducing vitrification and cellular preservation during desiccation	`DB-AIDP`
Biomaterials	Structural silk spidroins `silk_fiber`	239,011	10,955	Scored and simulated	Tandem poly-Ala/Gly cross-beta crystalline blocks for tensile structural biomaterials	`DB-SILK`
Biomaterials	Underwater marine coacervates `marine_adhesive`	27,919	20,014	Candidate	DOPA/cationic-rich adhesive domain for instantaneous cross-linking under saltwater	`DB-MAD`
Biomaterials	Barnacle cement adhesion complexes `barnacle_cement`	911,318	27,352	Scored and simulated	Cys-rich multi-protein complex forming durable underwater adhesive plaques	`DB-BCM`
Biomaterials	Abalone nacrein bioceramics `abalone_nacrein`	100,858	17,192	Candidate	Dual-domain carbonic anhydrase and Asp-rich matrix for tough aragonite nacre layers	`DB-ABN`
Biomaterials	Biophotonic reflectins `cuttlefish_reflectin`	4,111	29,831	Scored and simulated	Charge-tunable oligomerization domain for dynamic infrared and structural color reflection	`DB-CFR`
Biomaterials	Mechanobiotic stress sensors `mechanobiotic`	3,859,478	91,325	Candidate	Tension-gated channel architecture for force-activated cellular molecular switches	`DB-MBS`
Biomaterials	Tardigrade damage suppressors `tardigrade_dsup`	10,789,667	27,487	Scored and simulated	Basic alpha-helical chromatin clamp protecting DNA from hydroxyl radicals and ionizing radiation	`DB-DSUP`
Cellular Ag	Vegan cell-attachment proteins `serum_free_adhesion_scaffold`	41,266	26,653	Candidate	Microbially secreted RGD/LDV integrin matrix replacing fetal bovine serum (FBS) and mouse-tumor Matrigel	`DB-SFA1`
Cellular Ag	Rare sugar D-tagatose epimerases `rare_sugar_isomerases`	194,170	17,775	Scored and simulated	TIM-barrel catalytic cleft with Mn2+ coordination for zero-calorie allulose bio-manufacturing	`DB-RSI`
Therapeutics	TDP-43 / amyloid disaggregases `als_tdp43_disaggregase`	110,762	42,959	Scored and simulated	AAA+ hexameric motor pore threading and disassembling toxic cross-beta neurodegenerative amyloids	`DB-TDP43`
Therapeutics	Pan-prion amyloidolytic proteases `pan_prion_dissolution`	87,352	48,184	Candidate	Subtilisin-fold serine protease with deep hydrophobic cleft dismantling resilient prion fibrils	`DB-PRION`
Therapeutics	Gut indole-clearing monooxygenases (CKD) `feline_indoxyl_shield`	24,795	24,362	Candidate	Microaerophilic flavoprotein monooxygenase converting gut indole to prevent nephrotoxic indoxyl sulfate	`DB-FIS`
Therapeutics	Ultracompact CRISPR effectors `ultracompact_crispr_effector`	112,411	15,621	Candidate	Miniature RNA-guided endonuclease (<450 aa) for single-vector AAV therapeutic gene delivery	`DB-CRISPR`
Therapeutics	Microbial Cyclotide Macrocyclases `microbial_cyclotide_macrocyclase`	—^†	3,118	Not yet staged	Asparaginyl endopeptidase (AEP / legumain ligase) for peptide macrocyclization	`DB-MCM`	Provisional filed • dossier pending
Therapeutics	Macrocyclic CCK Knottins & Miniproteins `macrocyclic_cck_knottin`	—^†	36,378	Not yet staged	Protease-impermeable cyclic cystine knot (CCK) scaffold for oral peptides	`DB-CCK`	Provisional filed • dossier pending
Climate	Chloride-Immune Biobattery Cathodes `chloride_immune_biobattery_cathode`	—^†	2,240	Not yet staged	Multicopper oxidase 4e- reduction of O2 immune to 140 mM physiological chloride	`DB-MCO`	Provisional filed • dossier pending
Climate	Direct Electron Transfer Glucose Anodes `direct_electron_transfer_glucose_anode`	—^†	2,464	Not yet staged	Cytochrome-FAD glucose dehydrogenase for mediatorless biobattery anodes	`DB-GDH`	Provisional filed • dossier pending
Biomaterials	Wearable Sweat Lactate Biobattery Oxidases `lactate_sweat_biobattery_oxidase`	—^†	5,673	Not yet staged	Flavocytochrome b2 harvesting millimolar sweat lactate for wearable electronics	`DB-LOX`	Provisional filed • dossier pending
Therapeutics	Ciguatoxin-Binding Neutralizing Proteins `ciguatoxin_neutralizing_antidote`	—^†	29	Not yet staged	Aromatic binding groove capturing marine ciguatoxin neurotoxins	`DB-CTX`	Dossier pending
Polymers	Scrap Tire Polysulfide Devulcanases `rubber_crosslink_desulfurase`	—^†	253	Not yet staged	Surface-accessible sulfur-crosslink lyases cleaving vulcanized rubber networks	`DB-RCD`	Dossier pending
Polymers	Thermophilic Polyolefin Depolymerases `polyolefin_depolymerase`	—^†	103	Not yet staged	Multicopper polyolefin monooxygenases for crystalline PE & PP C-H abstraction	`DB-POD`	Dossier pending
Polymers	Silicone PDMS Depolymerases `siloxane_depolymerase`	—^†	42	Not yet staged	Lewis-acid assisted metallo-lyases cleaving Si-O-Si bonds in PDMS silicones	`DB-SLX`	Dossier pending
Climate	Hydrogen-Dependent CO2 Reductases (HDCR) `direct_co2_reductase_hdcr`	—^†	5	Not yet staged	Filamentous [FeFe]-FDH supercomplex for ambient direct CO2 reduction to formate	`DB-HDCR`	Dossier pending
Climate	Nitric Oxide Dismutases `nitric_oxide_dismutase`	—^†	2,308	Not yet staged	Anoxic oxygen-generating metalloenzyme converting 2 NO -> N2 + O2 directly	`DB-NOD`	Dossier pending
Climate	Marine Methylphosphonate Lyases `marine_methane_paradox_synthase`	—^†	9,869	Not yet staged	Metallo-hydrolase cleaving direct C-P bond in oceanic methylphosphonate	`DB-MPX`	Dossier pending
Therapeutics	Digoxin-Inactivating Gut Reductases `non_cgr_digoxin_reductase`	—^†	3,276	Not yet staged	Gut commensal ene-reductase reducing and inactivating cardiac glycosides	`DB-DGR`	Dossier pending
Therapeutics	Microbially Conjugated Bile Acid Amidases `noncanonical_bile_amidohydrolase`	—^†	2,039	Not yet staged	N-terminal nucleophile hydrolase cleaving aromatic amino acid-conjugated bile acids	`DB-BSH`	Dossier pending
Therapeutics	Radioprotective Mn2+-Binding Micropeptides `smorf_daly_radical_cage`	—^†	274	Not yet staged	18-35 AA micropeptide complexing Mn2+-phosphate for ionizing radiation protection	`DB-DRC`	Dossier pending
Biomaterials	Glass Sponge Biosilica Megasolenoids `hexactinellid_biosilica_solenoid`	—^†	5,956	Not yet staged	1,200-2,500 AA solenoid templating 3-meter fiber-optic spicules at 4°C	`DB-HBS`	Dossier pending
Climate	Radiotrophic Melanin Electron Conduits `radiotrophic_melanin_shuttle`	—^†	4,848	Not yet staged	Trans-wall multi-heme complex channeling Compton ionization electrons into ATP	`DB-RMS`	Dossier pending
Therapeutics	Hibernation-Inducing Torpor Microproteins `hibernation_trigger_peptide`	—^†	320	Not yet staged	Endogenous HIT microprotein inducing metabolic torpor and organ preservation	`DB-HIT`	Dossier pending
Minerals	Lithium-Selective Ionophores `lithium_selective_ionophore_protein`	—^†	14,128	Not yet staged	Neutral carbonyl cage for lithium over sodium selectivity in brines	`DB-LIP`	Dossier pending
Polymers	Thermoset Epoxy-Amine Matrix Cleavers `cured_epoxy_amine_cleaver`	—^†	190	Not yet staged	Flavoenzyme amine oxidase with a 9.4 Å bisphenol-A binding pocket for composite recycling	`DB-EAC`	Provisional filed • dossier pending
Minerals	Gold-Precipitating Metallochaperones `biological_gold_precipitating_chaperone`	—^†	87	Not yet staged	Deep-sea chaperone reducing toxic Au(III)/Au(I) to solid Au0 nanoparticles	`DB-GPC`	Dossier pending
Remediation	Anammox Hydrazine Dehydrogenases (HDH) `anammox_hydrazine_dehydrogenase`	—^†	395	Not yet staged	Multi-heme octaheme complex oxidizing toxic N2H4 directly to N2 gas	`DB-HDH`	Dossier pending
Minerals	Deuterium-Discriminating Aquaporins `deuterium_discriminating_aquaporin`	—^†	2,817	Not yet staged	Sub-angstrom stereochemical channel filtering H2O vs D2O via quantum zero-point effect	`DB-DDA`	Dossier pending
Biomaterials	Aqueous Boundary Biolubricants `super_lubricating_boundary_solenoid`	—^†	4,366	Not yet staged	Water-binding solenoid rods for low-friction coatings and joint/ocular lubrication	`DB-LUB1`	Dossier pending
Remediation	Deep Subsurface Toroidal Peroxiredoxins `deep_subsurface_radiolytic_peroxiredoxin`	—^†	10,999	Not yet staged	Zero-methionine (alpha2)5 decamer surviving extreme radiolytic peroxide fluxes	`DB-RPR`	Dossier pending
Polymers	Marine Agarose & Porphyran Depolymerases `marine_agarose_porphyrin_cleaver`	—^†	3,958	Not yet staged	Endo-beta-agarase cleaving sulfated marine red algal polysaccharides	`DB-APC`	Dossier pending

Candidate counts are mined sequences. Full-length 3D models counts whole modeled chains and leaves out chunk windows, which are partial fragments of a larger chain rather than standalone models; campaign counts are as of 7 November 2026 across 1.22M campaign-scored full-length 3D models (within a wider 2.93M-structure / 3.04M-chain structural library). Rows marked “Not yet staged” haven’t gone through biophysical scoring yet. † Screened against the unified metagenomic registry; dedicated campaign queues aren’t split out yet. ‡ Evaluated within the shared solenoid structure library.

Development stages

Every program is labeled with its current computational or synthesis milestone.

Candidate: Found by the screening pipeline, with a predicted structure and active-site motif. Not yet biophysically scored or simulated.
Scored and simulated: Passes full-length biophysical scoring and holds its fold in explicit-solvent molecular dynamics. No wet-lab assay yet.
CRO Synthesis Queued: Codon-optimized construct designed for a target host, ready for CRO synthesis on option execution.
Synthesized: Synthesized by a commercial peptide vendor, with identity and purity confirmed by HPLC and mass spectrometry. No wet-lab activity assay yet.

Partnering

Evaluate any candidate under bilateral CDA/MTA

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